Electric Literature of 698-00-0,Some common heterocyclic compound, 698-00-0, name is 2-Bromo-N,N-dimethylaniline, molecular formula is C8H10BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Under air, 1 (0.2 mmol), NH4I (0.8 mmol), 70% TBHP in water (2.4 mmol) and DMSO (0.5 mL) were added to a 10 mL Schlenk tube sealed with a Teflon lined cap. The reaction mixture was stirred at 90 C for 4 h in an oil bath. Upon completion, the reaction mixture was left to cool to room temperature and slowly quenched with anhydrous sodium sulfite. The reaction mixture was then diluted with ethyl acetate (5 mL) and then washed with water (5 × 5 mL). The aqueous layer was extracted with EtOAc (3 × 5 mL). The combined organic layers were dried over Na2SO4. The filtrate was concentrated and the crude product was purified by column chromatography on silica gel with petroleum ether (60-90 C)/ethyl acetate eluent. Characterisation data are consistent with literature data.
The synthetic route of 698-00-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Shao, Ying; Zheng, Hao; Wu, Zhuhong; Huang, Lei; Tong, Jingjing; Wu, Ming; Sun, Xiaoqiang; Journal of Chemical Research; vol. 41; 9; (2017); p. 504 – 508;,
Bromide – Wikipedia,
bromide – Wiktionary