698-19-1, name is 1-(2-Bromophenyl)-N-methylmethanamine, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 1-(2-Bromophenyl)-N-methylmethanamine
A mixture of compound 1A (4.30 g), [N-Boc-glycine] (3.01 g, 17.1 mmol), EDC (3.28 g, 17.1 mmol), and HOAt (2.34 g, 17.1 mmol) in DCM (50 ml) was stirred at rt overnight. The reaction was quenched with the addition of sat’d NaHCO3 solution. The organic layer was separated, washed with brine, dried MgSO4), and concentrated to give the crude product which was purified by flash chromatography (10-20% EtOAc/ hexane) to give compound 1B (3.35 g) as a colorless film.
The synthetic route of 698-19-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2004/788; (2003); A1;,
Bromide – Wikipedia,
bromide – Wiktionary