5910-12-3, name is 3-Bromopyrazolo[1,5-a]pyridine, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C7H5BrN2
REFERENCE EXAMPLE 1 3-(6-Fluoropyridin-2-yl)pyrazolo[1 ,5-a]pyridine To a 3-bromopyrazolo[1 ,5-a]pyhdine (2.40 g, 12.17 mmol) solution in DME (54 mL) under argon atmosphere, 6-fluoro-2-pyhdylboronic acid (1.80 g, 12.77 mmol), Pd(PPh3)4 (1.40 g, 1.21 mmol) and a solution of K2CO3 (3.70 g, 26.8 mmol) in H2O (7 mL) were added. The resulting mixture was heated at 85 0C for 5 h, cooled and concentrated to dryness. The crude product obtained was chromatographed over silica gel using hexane/EtOAc mixtures of increasing polarity as eluent, to afford 1.21 g of the desired compound (47% yield). LC-MS (Method 2): tR = 3.00 min; m/z = 214 (MH+).
The synthetic route of 5910-12-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PALAU PHARMA, S. A.; SALAS SOLANA, Jorge; ALMANSA ROSALES, Carmen; COMELLES ESPUGA, Josep; FONTES USTRELL, Montserrat; SOLIVA SOLIVA, Robert; PASTOR PORRAS, Jose, Javier; WO2010/72823; (2010); A1;,
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