Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 327-52-6, name is 1-Bromo-2,4,5-trifluorobenzene, A new synthetic method of this compound is introduced below., category: bromides-buliding-blocks
116.05g trifluorobromobenzene and 400ml tetrahydrofuran were added to a clean flask. The resulting mixture was cooled to -10 to -5C, and then 864ml (0.7mol) methyl magnesium bromide was added thereto dropwisely. The mixture was stirred for 1 hour for use. 23.5g (S)-methyl 3-(benzyloxycarbonylamino)-4-oxo n-butyrate was dissolved in 300ml THF, and added dropwisely to the mixture mentioned above and kept at this temperature for 3 hours after completion of the addition. 400ml solution of ammonium chloride was added dropwisely. Layers were separated. The aqueous layer was extracted with tetrahydrofuran (200ml X 2). The organic layer was dried and concentrated to get 31.4g (3S)-methyl 3-(benzyloxycarbonylamino)-4-hydroxy-4-(2,4,5-trifluorophenyl) butyrate (yield: 78.5%).
The synthetic route of 327-52-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Zhejiang Jiuzhou Pharmaceutical Co., Ltd.; EP2481722; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary