In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 22385-77-9, name is 1-Bromo-3,5-di-tert-butylbenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 22385-77-9
The title compound 1e was prepared according to a proceduredescribed by Zhu et al.31 Where 1-bromo-3,5-di-tert-butylbenzene(2.50 g, 9.30 mmol), CuI (0.177 g, 0.93 mmol), NaN3 (1.21 g,18.57 mmol), l-proline (0.321 g, 2.74 mmol) and NaOH (0.11 g,2.79 mmol) were added to EtOH:H2O (7:3, 20 mL) and heated to95 C in a sealed tube for 23 h. The reaction mixture was thenadded water (30 mL) and extracted with EtOAc (3 30 mL). Dryingover MgSO4 and evaporation under reduced pressure yielded a yellowoil, which then was purified using flash column chromatography(pentane), affording 1e as a colorless oil (0.725 g, 3.13 mmol,34percent). 1H NMR spectra coincided with previously reported data.441H NMR (400 MHz, CDCl3): d 7.20 (t, 1H, J = 1.5 Hz, HPh-4), 6.86(d, 2H, J = 1.6 Hz, HPh-2 and HPh-6), 1.31 (s, 18H, 2 t-Bu).
The synthetic route of 22385-77-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Bakka, Thomas A.; Str°m, Morten B.; Andersen, Jeanette H.; Gautun, Odd R.; Bioorganic and Medicinal Chemistry; vol. 25; 20; (2017); p. 5380 – 5395;,
Bromide – Wikipedia,
bromide – Wiktionary