Application of 2789-89-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2789-89-1 name is 1,2-Bis(4-bromophenyl)ethyne, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: To an oven-dried screwed vial were added substituted 2-oxo-2-phenylacetic acid (0.1mmol), substituted alkyne (0.11mmol), [IrCp*Cl2]2 (0.01mmol, 7.97mg), (CH3OC6H4)3P (0.01mmol, 3.52mg), AgSbF6 (0.01mmol, 3.44mg), Cu(OAc)2 (0.02mmol, 3.99mg), and toluene (1mL). The mixture was vigorously stirred at 120C under air to the end of the reaction. Organic solvents were removed in vacuo, and then the residue was purified by a silica gel column chromatography to give the desired product.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,2-Bis(4-bromophenyl)ethyne, and friends who are interested can also refer to it.
Reference:
Article; Yu, Xiaobo; Geng, Shudong; Liu, Guanchen; Guo, Weijie; Wang, Jianhui; Journal of Organometallic Chemistry; vol. 879; (2019); p. 139 – 143;,
Bromide – Wikipedia,
bromide – Wiktionary