Adding a certain compound to certain chemical reactions, such as: 960203-41-2, name is (2-Bromophenyl)(2,4-dimethylphenyl)sulfane, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 960203-41-2, Quality Control of (2-Bromophenyl)(2,4-dimethylphenyl)sulfane
Under nitrogen protection, In a 500-mL reactor were charged 13.8 g (0.1 mol) The compound of the formula (4) 2,4-dimethylthiophenol, 28.3 g (0.1? Bromoiodobenzene, 53.0 g (0.25 mol) Potassium phosphate and 1. 9 g (0. Olmol) Cuprous iodide, 1.15 g (0.01 mol) L-proline, 300 mL of dimethylformamide was added, Stirring heated to 70-80 ° C, Reaction 5h, After completion of the reaction, To the reaction solution, 9. 46 g (0.11 mol) Piperazine, Heating was continued for 5-8 hours, After completion of the reaction, a portion of the solvent was distilled off. The residue was added with water and extracted three times with 300 ml of methylene chloride. The organic layers were combined, dried and evaporated to give methylene chloride. The residue was recrystallized from 200 mL of acetonitrile to give 28.8 g of a white solid, yield 96.7percent, purity 99.2percent (HPLC): Luna Phenyl-Hexyl column (4.6 mm × 150 mm, 3 um) was used as the mobile phase. The mobile phase consisted of 0 · 05percent trifluoroacetic acid (60:40) Temperature 40 ° C; flow rate lml / min].
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Reference:
Patent; Feng, Xiuwu; (7 pag.)CN104098530; (2016); B;,
Bromide – Wikipedia,
bromide – Wiktionary