Reference of 67567-26-4, The chemical industry reduces the impact on the environment during synthesis 67567-26-4, name is 4-Bromo-2,6-difluoroaniline, I believe this compound will play a more active role in future production and life.
A solution of 4-bromo-2,6-difluoroaniline (15g) in dry DMF (180ml) was degassed for SOmin. Water (42ml) was added and the solution was further degassed for 10min. n-Butyl vinyl ether (46.60ml), 1,3-bis(diphenylphosphiho)propane (1.96g), potassium carbonate (11.76g), and palladium (II) acetate (0.48g) were added and the mixture was stirred at 80C under nitrogen for 6h and then at ambient temperature for 18h. The5 mixture was concentrated under reduced pressure. The residue was partitioned between ethyl acetate and water. The separated organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was treated with MeCN (100ml), water (100ml) and formic acid (2ml) and stirred at ambient temperature for 45min. The mixture was concentrated under reduced pressure and partitioned between) DCM and saturated aqueous sodium bicarbonate solution. The separated organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by flash vacuum chromatography (silica, eluting withether). Trituration with cyclohexane afforded a solid which was filtered and dried undervacuum at ambient temperature to give the title compound (10.47g) as a cream solid.Mass spectrum: Found MM* 172H.p.l.c. Rt 2.27 min
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-2,6-difluoroaniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GLAXO GROUP LIMITED; WO2004/110997; (2004); A1;,
Bromide – Wikipedia,
bromide – Wiktionary