Related Products of 156682-52-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 156682-52-9 as follows.
A solution of intermediate 4 (5 g, 18.1 mmol), 1,4-dibromo-2,3-difluorobenzene (2.4 g, 9.0 mmol), tetrakis (triphenylphosphine) palladium (0) mmol) is added to a mixed solvent of tetrahydrofuran (60 ml) and potassium carbonate 2M solution (20 ml) and refluxed for 24 hours. After the reaction was completed, the reaction solution was extracted with methylene chloride, and then subjected to column chromatography using a methylene chloride / hexane mixed solvent as a developing solvent to obtain 4.3 g of Intermediate 5.
According to the analysis of related databases, 156682-52-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; LG Chem, Ltd.; Dankook University Cheonan Campus Industry-Academic Cooperation Foundation; Gu Gi-dong; Lee Gi-gon; Keum Su-jeong; Kim Gong-gyeom; Lee U-cheol; Lee Chil-won; Cha Jae-ryeong; Joo Yun-seok; (30 pag.)KR2018/106234; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary