Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 327-51-5, name is 1,4-Dibromo-2,5-difluorobenzene, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C6H2Br2F2
The compound 2,5-difluoro-1,4-dibromobenzene (2 g, 7.40 mmol) was sequentially added to a 100 mL single-necked flask, (4.7 g, 18.52 mmol), potassium acetate (4 g, 44.40 mmol), Pd(dppf)Cl2 (210 mg, 0.287 mmol) and 1,4-dioxane (25 mL) The temperature was raised to 80 under reflux for 24h. Stop the reaction and cool, the reaction solution was washed with saturated brine 4 times, extracted with DCM twice, the combined organic phase, Dried over anhydrous MgSO4 overnight, filtered and the organic solvent was spun off. The crude product was extracted with PE-DCM (v / v, 2/1) as eluent, and then recrystallized from n-hexane to give 2 g of white needle-like crystals, Yield: 74.1%
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 327-51-5.
Reference:
Patent; Changzhou University; Liu Yu; Liu Yajun; Zhu Weiguo; Wang Yafei; (26 pag.)CN107400147; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary