Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 43204-63-3, name is Bis(2-Bromoethyl)amine hydrobromide, A new synthetic method of this compound is introduced below., COA of Formula: C4H10Br3N
To a mixture of 5-amino-3,4-dihydroquinolin-2(1H)-one 1(5.00 g, 30.83 mmol), bis(2-bromoethyl)amine hydrobromide(9.05 g, 33.91 mmol) and water (40 mL), a solution of potassiumhydroxide (1.90 g, 33.91 mmol,10 mL)was added dropwise at 80 C.Then the reaction mixture was stirred at 100 C for 3 h. The progressof the reaction was monitored by TLC. After the reaction wascompleted, the reaction mixture was cooled to the room temperature.The mixture was filtered and the filtrate was adjusted toPH 10 with the 10% aqueous solution of potassiumhydroxide. Theresultant solid was filtered, washed with water to afford 6.4 g of 5-(piperazin-1-yl)-3,4-dihydroquinolin-2(1H)-one 2 as a white solid.Yield 61%, m. p. 235e237 C; 1H NMR (300 MHz, DMSO-d6) d: 10.01(s, 1H, quinolin, eCONHe), 7.07 (t, J 7.9 Hz, 1H, quinolin-H7), 6.65(d, J 8.0 Hz, 1H, quinolin-H8), 6.58 (d, J 7.8 Hz, 1H, quinolin-H6),3.94 (s, 1H, NH), 2.82e2.94 (m, 4H, quinolin-H4 and eCH2-),2.67e2.84 (m, 6H, eCH2-), 2.35 (t, J 7.3 Hz, 2H, quinolin-H3); 13CNMR (75 MHz, DMSO-d6) d: 170.59, 150.18, 139.44, 127.33, 117.62,112.55, 110.18, 51.34, 46.73, 30.16, 20.38; LC-MS (ESI): m/z 232[MH].
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Ji, Qinggang; Deng, Qiao; Li, Bing; Li, Baihui; Shen, Yangli; European Journal of Medicinal Chemistry; vol. 180; (2019); p. 204 – 212;,
Bromide – Wikipedia,
bromide – Wiktionary