Synthetic Route of 615-54-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 615-54-3, name is 1,2,4-Tribromobenzene, This compound has unique chemical properties. The synthetic route is as follows.
6.296 (0.02 mol) 1,2,4-tribromobenzene and 8.671 g (0.05 mol)3-aminobenzeneboronic acidHydrochlorideAdd to a 500 mL three-necked flask, add 400 mL of tetrahydrofuran (THF), and add 45 mL of 2 mol/L potassium carbonate solution.And add an appropriate amount of aliquat336, magnetically stirred and argon gas, after heating to 75 C in the oil bath,0.020 g of tetrakistriphenylphosphine palladium was added, and the reaction was refluxed for 24 hours, and the reaction liquid was poured into water to precipitate a large amount. The mixture was filtered with a funnel, and the solvent was evaporated under reduced pressure.The product was purified by column chromatography using dichloromethane: n-hexane = 2:1 (volume ratio) as mobile phase as the stationary phase. The product was collected and dried.Drying in a vacuum at 90 C for 24 h,The target product was obtained 5.834 g,The yield was 83%.
The chemical industry reduces the impact on the environment during synthesis 1,2,4-Tribromobenzene. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Hunan University of Technology; Ke Shenghai; Liu Yiwu; Tan Jinghua; Zhu Heping; (19 pag.)CN108976138; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary