Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 103-64-0, name is (2-Bromovinyl)benzene, A new synthetic method of this compound is introduced below., COA of Formula: C8H7Br
To a solution of an appropriate amount of an organic solvent (a mixture of N, N-dimethylformamide (DMF) and polyethylene glycol 200 (PEG-200) in a volume ratio of 4: 1)100 mmol of the compound of formula (I)40 mmol of the compound of formula (II)11 mmol of catalyst bis (triphenylphosphine) cyclopentadienyl ruthenium chloride,100 mmol Oxidant Bis (trifluoroacetic acid) iodobenzene (PhI (TFA) 2),20 mmol of organic ligands L1,60 mmol of base,5,7-triazabicyclo [4.4.0] dec-5-ene (TBD) and 10 mmol activator niobium pentachloride,Then the mixture was warmed to 70 C with stirring, and the reaction was stirred at that temperature for 12 hours;;After completion of the reaction, the reaction system is naturally cooled to room temperature and the pH is adjusted to neutral, filtered and the filtrate is saturated Washed with brine and extracted with ethyl acetate 2-3 times. The combined organic phases were dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was passed through Silica gel column chromatography eluting with a 1: 2 by volume mixture of chloroform and petroleum ether to give a compound of the above formula (III) The yield was 89.5%.
The synthetic route of 103-64-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Huang Cheng; Bu Gonggaofamingren; (11 pag.)CN106278838; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary