Synthetic Route of 626-39-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 626-39-1 name is 1,3,5-Tribromobenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
1,3,5-Tribromobenzene (20 g, 62 mmol), Pd(PPh3)4 (3.57 g, 3.1mmol) were added to 300 mL of dry THF solution, thenphenylbronic acid (32 g, 155 mmol) and 2 M K2CO3 solution (50 mL), which was dissolved in H2O, was added to the reaction mixture. The reaction mixture was heated to 65C for 5 h under nitrogen. After the reaction was finished,extracted with diethyl ether and water. The organic layer was dried with anhydrous MgSO4 and filterd. The solvent was evaporated. The product was isolated by silica gel column chromatography using CHCl3:hexane (1:15) eluent to afforda white solid (Yield 61%). 1H NMR (300 MHz, CDCl3) delta 7.7(s, 3H), 7.6 (d, 4H), 7.45 (t, 4H), 7.4 (t, 2H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,3,5-Tribromobenzene, and friends who are interested can also refer to it.
Reference:
Article; Shin, Hwangyu; Kang, Hyeonmi; Kim, Beomjin; Park, Youngil; Yu, Young-Jun; Park, Jongwook; Bulletin of the Korean Chemical Society; vol. 35; 10; (2014); p. 3041 – 3046;,
Bromide – Wikipedia,
bromide – Wiktionary