Related Products of 1003-98-1, These common heterocyclic compound, 1003-98-1, name is 2-Bromo-4-fluoroaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Reference Example 10: methyl [(lR)-6-fluoro-8-(methylsulfonyl)-2, 3,4, 9-tetrahydro-lH-carbazol-l- yl] acetate Step 1: 2-(2-bromo-4-fluorophenyl) hydraziniumchloride To a suspension of 2-bromo-4-fluoroaniline in concentrated HCI (1. 5M) at-10 C was slowly added a 10. 0M aqueous solution of NaNO2 (1.1 eq). The mixture was stirred at 0 C for 2.5 hrs. A cold (-30 C) solution of SnCl2 (3. 8M) in concentrated HCI was then slowly added while maintaining the internal temperature below 10 C. The resulting mixture was stirred mechanically for 20 min at 0, then at room temperature for 1 hr. The thick slurry was filtered and the solid was air dried overnight. The solid was resuspended in cold HCI and filtered again. The dried material was suspended in Et2O, stirred for 10 min, filtered and air dried overnight to give the title compound as a beige solid.
Statistics shows that 2-Bromo-4-fluoroaniline is playing an increasingly important role. we look forward to future research findings about 1003-98-1.
Reference:
Patent; MERCK FROSST CANADA & CO.; WO2005/56527; (2005); A1;,
Bromide – Wikipedia,
bromide – Wiktionary