Synthetic Route of 43204-63-3, A common heterocyclic compound, 43204-63-3, name is Bis(2-Bromoethyl)amine hydrobromide, molecular formula is C4H10Br3N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Add 5-amino-3,4-dihydroquinolin-2(1H)one 7 (5.00 g, 30.83 mmol) to 40 ml of water in turn, di-(2-bromoethyl)amine hydrobromide (50.57 g, 33.91 mmol), stirring to 80 C, An aqueous solution of potassium hydroxide (1.90 g, 33.91 mmol, 10 ml) was added dropwise in three portions over half an hour. After the addition is completed, the reaction is heated to 100 C. The reaction was further incubated for 3 hours. After completion of the reaction, the mixture was cooled to room temperature, filtered, and the filtrate was adjusted to pH 10 with a 10% aqueous potassium hydroxide solution to precipitate a large white solid. Filtered, washed with a suitable amount of water, dried to give a white powdery solid 8 (6.4 g, yield 61%, Mp 235-237 C);
The synthetic route of 43204-63-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Southwest University; Ji Qinggang; Deng Qiao; (15 pag.)CN109438344; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary