These common heterocyclic compound, 2924-09-6, name is 5-Bromo-2-fluoroaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: bromides-buliding-blocks
5-Bromo-2-fluoroaniline (2.85 g, 15.00 mmol) and 4-methylmorpholine (1.65 mL, 15.00 mmol) were dissolved in anhydrous dichloromethane (20 mL) and the solution was cooled to -20 C. Add compound 5 (3.55 g, obtained in the synthesis of steps 1-3,13.66 mol), the mixture was slowly warmed to 20 C and kept stirring at 20 C for 12 hours. The resulting red suspension was poured into water (80 mL). The phases were separated and the organic layer was dried with Na2SO4, filtered and evaporated.A red oil was obtained and the residual red oil was dissolved in methanol (20 mL).The solution was heated to reflux for 1 hour to form a precipitate. The mixture was cooled to 4 C.The precipitate was collected by filtration, washed with methanol and dried to give a pale pink solid.N-(5-Bromo-2-fluorophenyl)-6-(furan-2-yloxy)pyridine-3-sulfonamide (Compound 6), 3.50 g, yield 62%.
The synthetic route of 5-Bromo-2-fluoroaniline has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Dou Yuling; (11 pag.)CN108484585; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary