A new synthetic route of 5-Bromo-2-methylpent-2-ene

The chemical industry reduces the impact on the environment during synthesis 5-Bromo-2-methylpent-2-ene. I believe this compound will play a more active role in future production and life.

Synthetic Route of 2270-59-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2270-59-9, name is 5-Bromo-2-methylpent-2-ene, This compound has unique chemical properties. The synthetic route is as follows.

1.55 kg of magnesium and 10 kg of THF are charged into a stainless steel reactor provided with liquid nitrogen cooling . This is heated under reflux (60-700C) and, still at that temperature, 0.5 I of the solution containing 10 kg of 5-bromo-2-methyl- pentene (II) at 100% is poured. This is kept under reflux for at least 10 minutes until the reaction starts. The reaction mixture is then cooled to 50-600C and, keeping it at that temperature with a brine bath, the remaining solution of 5-bromo- 2-methyl-pentene (II) in THF is poured. The reaction mixture is kept at 50-600C for at least 1.5 hours and 40 kg of THF are added. The reaction mixture is then cooled with liquid nitrogen to -65/-700C and at that temperature 7.2 kg of diethyloxalate are added. The reaction mixture is kept at -65/-700C for at least 1 hour, under EPO stirring. The mixture thus obtained is then poured into another enamelled reactor containing 10kg of 32% hydrochloric acid dissolved in 30 kg of demineralised water and previously cooled to 0-100C.The reaction mixture is then brought to 20-300C and left until the phases separate. The aqueous phase is removed, while the organic phase is washed at 20-300C with 0.25 kg of sodium bicarbonate dissolved in 5 kg of demineralised water. The reaction mixture is stirred at the same temperature and left until the phases separate. The lower aqueous phase is removed, while the solvent is removed from the organic phase by vacuum distillation until an oily residue is obtained. Then 15 kg of THF are added and the mixture obtained is stirred until a solution is obtained which is sent to the next stage. Yield not determined.

The chemical industry reduces the impact on the environment during synthesis 5-Bromo-2-methylpent-2-ene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; ERREGIERRE S.p.A.; STRAGEN PHARMA SA; WO2007/9953; (2007); A1;,
Bromide – Wikipedia,
bromide – Wiktionary