Adding a certain compound to certain chemical reactions, such as: 656-64-4, name is 3-Bromo-4-fluoroaniline, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 656-64-4, name: 3-Bromo-4-fluoroaniline
3-bromo-4-fluoroaniline (415mg, 2.18mmol), cyclopropylboronic acid (244mg, 2.84mmol), Pd (OAc) 2 (25mg, 0.11mmol), tricyclohexylphosphine (61mg, 0.22mmol), Potassium phosphate (1.62g, 7.64mmol) was dissolved in toluene (12mL) and water (1mL), protected by argon, and reacted at 100 C for 16h. The raw materials disappeared. Cool to room temperature, add EA (20 mL), wash with saturated brine (20 mL × 2), wash with water (20 mL × 2), and column chromatography (P / E = 10: 1) to obtain 235 mg of brown oil, yield 71.2% .
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Bromo-4-fluoroaniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Xu Boling; Chen Xiaoguang; Cui Guonan; Lai Fangfang; Zhou Jie; Ji Ming; Wang Xiaoyu; Du Tingting; Li Ling; Jin Jing; (144 pag.)CN110483366; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary