Electric Literature of 112734-22-2, The chemical industry reduces the impact on the environment during synthesis 112734-22-2, name is (4-Bromo-2-fluorophenyl)methanamine, I believe this compound will play a more active role in future production and life.
Preparation of 3-[(4-bromo-2-fluorobenzyl)amino]-1-propanesulfonic acid 4-Bromo-2-fluorobenzylamine hydrochloride (5.0 g, 20.8 mmol) was treated with a saturated solution of K2CO3 (80 mL) and EtOAc (3*80 mL) was added. The organic extracts were combined, dried with Na2SO4, filtered, evaporated under reduced pressure and dried in vacuo. To a solution of 4-Bromo-2-fluorobenzylamine (20.8 mmol) in 50% Pinacolone/Toluene (25 mL) was added 1,3-propane sultone solution (2.3 g, 18.9 mmol). The solution was stirred at reflux for 4 hours. The reaction mixture was cooled to room temperature. The solid material was collected by filtration and washed with acetone (2*20 mL). The solid was suspended in EtOH (40 mL). The suspension was stirred at reflux for 1 hour. The mixture was cooled to room temperature, the solid material was collected by filtration, washed with acetone (2*20 mL) and dried in a vacuum oven (50 C.), affording the title compound, 4.42 g (65%). 1H NMR (D2O, 500 MHz) delta ppm 7.35 (m, 2H), 7.26 (t, 2H, J=7.8 Hz), 4.16 (m, 2H), 3.11 (t, 2H, J=7.8 Hz), 2.85 (t, 2H, J=7.6 Hz), 2.00 (m, 2H). 13C (D2O, 125 MHz) delta ppm 161.98, 159.97, 133.37, 128.50, 124.39, 124.31, 119.79, 119.60, 117.32, 117.19, 48.00, 46.15, 44.40, 21.34. 19F (D2O, 282 MHz) delta ppm -114.64. ES-MS 325 (M-1).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (4-Bromo-2-fluorophenyl)methanamine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Kong, Xianqi; Wu, Xinfu; Bouzide, Abderrahim; Valade, Isabelle; Migneault, David; Bellini, Francesco; US2006/183800; (2006); A1;,
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bromide – Wiktionary