Adding a certain compound to certain chemical reactions, such as: 7051-34-5, name is (Bromomethyl)cyclopropane, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7051-34-5, HPLC of Formula: C4H7Br
Cyclopropyl methyl bromide (1.4 ml, 14.46 mmol), sodium iodide (0.986 g, 6.6 mmol) and potassium carbonate (3.64 g, 26.3 mmol) were added sequentially to a stirred solution of 4-hydroxybenzoic acid methyl ester (2.0 g, 13.14 mmol), in 25 ml of acetone at room temperature and the mixture was refluxed for 44 h. The solvent was evaporated to obtain a residue to which 10% NaOH (80 ml) was added. The solution was extracted with DCM twice. The combined DCM layers were washed with water and brine and dried over anhydrous Na2SO^ The solvent was evaporated to obtain 2.5 g (92.25%) of 4- cyclopropylmethoxybenzoic acid methyl ester. LCMS: [M+H]+ 270.3; IH-NMR (CDCl3): 7.964-7.986 (d, 2H, J=8.8 Hz), 6.895-6.917 (d, 2H, J=8.8 Hz), 3.879 (s, 3H), 3.849-3.867 (d, 2H, J=7.2 Hz), 1.262-1.281 (m, IH), 0.639-0.671 (m, 2H), 0.360-0.372 (m, 2H).
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Reference:
Patent; FOREST LABORATORIES HOLDINGS LIMITED; SARMA, Pakala, Kumara Savithru; ACHARYA, Vinod, Parameshwaran; KASIBHATLA, Srinivas, Rao; VISWANADHAN, Vellarkad, Narayana; SHEKHAR, Polisetti; BISCHOFF, Alexander; WO2010/127212; (2010); A1;,
Bromide – Wikipedia,
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