Electric Literature of 51436-99-8, These common heterocyclic compound, 51436-99-8, name is 4-Bromo-2-fluorotoluene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 29 Preparation of 2-fluoro-4-cyanotoluene (38) Copper(I) cyanide (Aldrich, 3.6 g, 40 mmol) was added to a solution of 4-bromo-2-fluorotoluene (Aldrich, 5 g, 27 mmol) in DMF (60 mL). The reaction mixture was heated at 150 C. for 11 hours. After cooling to room temperature, the mixture was partitioned between water and EtOAc (500 mL each). The organic layer was dried (MgSO4), and solvent was removed under vacuum to give the title compound (2.08, 58%). 1H-NMR (CDCl3) delta2.36 (s, 3H), 7.30 (m, 3H), 7.35 (d, 1H, J=8.1 Hz).
The synthetic route of 51436-99-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Corvas International, Inc.; US6541467; (2003); B1;,
Bromide – Wikipedia,
bromide – Wiktionary