Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 858121-94-5, name is 4-(Bromomethyl)-1,1-difluorocyclohexane, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 4-(Bromomethyl)-1,1-difluorocyclohexane
General procedure: DIPEA (778 muIota, 4.46 mmol) was added dropwise to a stirred solution of N-(2-hydroxyethyl)-4- (2H-tetrazol-5-yl)benzenesulfonamide (300 mg, 1.1 14 mmol, Intermediate 17′) and 2- (bromomethyl)tetrahydro-2H-pyran (285 muIota, 2.228 mmol, commercial source: Aldrich) in N,N- Dimethylformamide (DMF) (3714 muIota) at rt under nitrogen. The mixture was stirred at rt for 3 days. As starting material remained, it was stirred at 70 C overnight. The mixture was concentrated under reduced pressure. The crude compound was purified by flash column chromatography (silica; EtOAc-cyclohexane from 0/100 to 50/50). The desired fractions were collected and concentrated in vacuo to obtain the product as a racemic mixture N-(2- hydroxyethyl)-4-(2-((tetrahydro-2H-pyran-2-yl)methyl)-2H-tetrazol-5-yl)benzenesulfonamide (49 mg, 0.133 mmol, 28%). NMR (400 MHz, Acetone-d6) delta 7.84-7.78 (m, 2H), 7.56-7.50 (m, 2H), 7.33 (t, J = 5.9 Hz, 1 H), 4.37-4.32 (m, 2H), 4.25 (t, J = 5.6 Hz, 1 H), 3.50-3.44 (m, 1 H), 3.38-3.32 (m, 1 H), 2.94-2.90 (m, 2H), 2.86-2.80 (m, 1 H), 2.41-2.37 (m, 2H), 1.40-1.25 (m, 2H), 1.12-0.85 (m, 4H). MS m/z [M-H]”= 366.2
According to the analysis of related databases, 858121-94-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ALEMPARTE-GALLARDO, Carlos; ENCINAS, Lourdes; ESQUIVIAS PROVENCIO, Jorge; (206 pag.)WO2019/34729; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary