Electric Literature of 626-40-4,Some common heterocyclic compound, 626-40-4, name is 3,5-Dibromoaniline, molecular formula is C6H5Br2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Compound II-2 (2.51 g, 10 mmol), Compound III (2.06 g, 10 mmol), Pd(OAc)2 (0.22 g, Lmmol), BINAP (2,2,-bisdiphenylphosphino-1,1′-binaphthyl, 0.62g, 1mmol) and t-BuOK (2.24g, 20mmol) plus Into 50 mL of dry 1,2-dimethoxyethane (DME), the reaction mixture was stirred overnight under a nitrogen atmosphere and TLC detection was performed. The reaction is now complete. The reaction mixture was carefully poured into 200 mL of ice water, stirred, extracted with 50 mL of X 3 CH 2 Cl 2 , and the extraction phases were combined. It was washed with 1% dilute hydrochloric acid and brine and dried over anhydrous sodium sulfate. The desiccant is filtered off with suction and the filtrate is evaporated to dryness on a rotary evaporator. The residue was purified using silica gel column chromatography to give compound IV-2.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,5-Dibromoaniline, its application will become more common.
Reference:
Patent; Guangdong Sai Bo Technology Co., Ltd.; Guo Huijun; (8 pag.)CN108003169; (2018); A;,
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