Synthetic Route of 1003-99-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1003-99-2 name is 2-Bromo-5-fluoroaniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
2-1 (200 g, 1053 mmol) and diethyl ethoxymethylenemalonate (228 g, 1053 mmol) were combined neat and heated to 120 “C. After 2 h, the reaction was poured hot into 2 L of methanol. The resulting mixture was cooled to 10 C and filtered, washing with methanol. The product was dried on the filter under N2, yielding 320 g (84%) of 2-2 in two crops. MS (Electrospray): m/z 315.9 (MH+-CO2)-
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromo-5-fluoroaniline, and friends who are interested can also refer to it.
Reference:
Patent; MERCK & CO., INC.; WO2008/2621; (2008); A2;,
Bromide – Wikipedia,
bromide – Wiktionary