In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2862-39-7 as follows. name: 2-Bromo-N,N-dimethylethanamine hydrobromide
A mixture of tert- butyl 5-{N-[(4-methoxyphenyl)methyl]3-fluoro-4-[2-(1H-imidazol-1-yl)acetamido]benzenesulfonamido}-1,3-thiazole-4-carboxylate (Example 20a) (250 mg, 0.4 mmol), dimethylaminoethyl bromide hydrobromide salt (Sigma Aldrich) (120 mg, 2.07 mmol) and DIPEA (0.61 mL, 3.3 mmol) in acetonitrile (30 mL) was heated at 80 C for 72 hours. The mixture was evaporated and the residue triturated with methanol-ether affording a brown solid (300 mg).
According to the analysis of related databases, 2862-39-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Antabio SAS; DAVIES, David; LEIRIS, Simon; (56 pag.)EP3572411; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary