Related Products of 185122-74-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 185122-74-1 name is 5-Bromo-2,3-dihydro-1H-inden-1-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Compound C (2.5 g, 10.5 MMOL) was dissolved in MEOH (40 mL) and reacted with SNCI2-2H2O (4. 7 g, 20.8 MMOL) at rt overnight. The solvent was removed and NAOH (aq, 1 N, 50 mL) was added. The reaction mixture was extracted into EtOAc (50 mL). The organic layer was extracted with HCI (1 N, 50 mL x 2) and the aquoues layer was basified with solid NaOH until the pH was about 11. The mixture was extracted with EtOAc (50 mL x 3). The organic layers were combined and dried over NA2SO4 and then concentrated to give the corresponding amine. The amine was dissolved in CH2CI2 (50 mL) and cooled TO-78 C. TFAA (1.47 g, 6.9 MMOL) was added followed by slow addition of Et3N (1.05 g, 10.4 MMOL). The reaction mixture was slowly warmed up to rt and stirred for 3 h. H20 (50 mL) was used to wash the reaction mixture. The organic layer was washed with brine, then dried over NA2SO4, and concentrated to dryness. The crude product was purified via sgc (25% EtOAc/hexanes) to give 3.1 g (96%) of compound D.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Bromo-2,3-dihydro-1H-inden-1-amine, and friends who are interested can also refer to it.
Reference:
Patent; SCHERING CORPORATION; WO2004/48322; (2004); A1;,
Bromide – Wikipedia,
bromide – Wiktionary