Adding a certain compound to certain chemical reactions, such as: 348-57-2, name is 1-Bromo-2,4-difluorobenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 348-57-2, HPLC of Formula: C6H3BrF2
To a 0 C. mixture of 1-bromo-2,4-difluorobenzene (20.0 g; 11.7 mL; 0.100 mol) and H2SO4 (76.8 mL) was added HNO3 (68.0 mL) over 45 min at such a rate that the internal temperature was < 7 C. The resulting mixture was stirred for 1 h at 0 C., poured into ice water (400 mL), stirred vigorously for 2-3 min and extracted with CH2Cl2 (400 mL). The CH2Cl2 extract was washed with brine (1?500 mL), dried over Na2SO4, filtered and evaporated to give the product as a yellow oil (23.5 g, 95percent). 1H NMR (300 MHz, CDCl3) ? 7.14 (ddd, J=0.3, 7.8, 9.9 Hz, 1H), 8.39 (t, J=7.2 Hz, 1H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-2,4-difluorobenzene, and friends who are interested can also refer to it.
Reference:
Patent; Synaptic Pharmaceutical Corporation; US2005/154020; (2005); A1;,
Bromide – Wikipedia,
bromide – Wiktionary