583-70-0, name is 2,4-Dimethylbromobenzene, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C8H9Br
Under a nitrogen atmosphere, cuprous iodide (3.0 mol%, 0.7 mg), sodium iodide (1.0 equiv., 18.7 mg) and magnets were added to a previously baked 10 mL glass pressure tube. Dioxane (0.2 mL), 2,4-dimethylbromobenzene (0.125 mmol, 1.0 equiv., 23.2 mg) and N,N’-dimethylethylenediamine (10.0 mol%, 1.1 mg) were then added. ). After the addition was completed, the glass pressure tube was placed in a metal module that had been preheated to 100 deg C and stirred for 10 hours. After cooling to room temperature, copper powder (20 mol%, 1.6 mg), aluminum chloride (3 mol%, 0.5 mg), N-methylpyrrolidone (0.5 mL) and polymethylhydrogensiloxane (3.0 equiv) were added under a nitrogen atmosphere. ., 83.4mg). The tube was purged of air and charged with carbon dioxide (5.0 equiv., 15 mL) and ammonia gas (5.0 equiv., 15 mL). After the addition was completed, the reactor was placed in a metal module preheated to 160 deg C and stirred for 10 hours. After the reaction was completed, the reaction system was cooled to room temperature and pressure was slowly released. Using dodecane as an internal standard, the yield of the gas chromatogram was determined to be 78%.
The synthetic route of 583-70-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Chinese Academy Of Sciences Lanzhou Chemical Physics Institute Suzhou Institute; Li Yuehui; Wang Hua; Dong Yanan; Ke Lisitian·shanduofu; (20 pag.)CN108017557; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary