Reference of 22385-77-9,Some common heterocyclic compound, 22385-77-9, name is 1-Bromo-3,5-di-tert-butylbenzene, molecular formula is C14H21Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The reaction flask was sequentially charged with raw materials la (56 mg, 0.2 mmol) and 21 (1 mL), cesium carbonate (130 mg, 2.0 eq), dilute ligand L2-1 (2.6 mg, 5 molpercent), tricyclohexylphosphine tetrafluoroboron Acid salt (1.8 mg, 2.5 molpercent), [Rh (cod) Cl] 2 (2.5 mg, 2.5 molpercent), di-tert-butylphosphonium chloride (18 mg, 0.1 mmol) and toluene (2 mL) in nitrogen In an atmosphere, the mixture was stirred at 120 ° C for 24 hours, cooled to room temperature, diluted with ethyl acetate (5 mL), diluted with EtOAc (2 mL), and brine (5 mL) After spin-drying column chromatography, the eluent was (ethyl acetate/petroleum ether = 1/15) to give product 3a as a white solid 24 mg, yield 18percent.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-3,5-di-tert-butylbenzene, its application will become more common.
Reference:
Patent; UNIV NANKAI; Nankai University; YE MENGCHUN; Ye Mengchun; YANG JINFEI; Yang Jinfei; (18 pag.)CN107840784; (2018); A;,
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