Reference of 583-75-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 583-75-5, name is 4-Bromo-2-methylaniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a solution of 70 4-bromo-2-methylaniline (10.5g, 56.3mmol) in 71 acetic acid (300mL) were added 21 NaNO2 (3.89g, 56.3mmol) and 72 water (10mL). After stirring at room temperature for 5h, the reaction mixture was concentrated in vacuo. The residue was diluted with EtOAc and washed with saturated aqueous NaHCO3 solution and brine. The organic layer was dried over anhydrous Na2SO4, filtered, and concentrated in vacuo. The residue was purified by silica gel column chromatography (0-50% 73 EtOAc in hexanes) and solidified with hexanes to afford 13 6 as a brown solid (6.81g, 61% yield). 1H NMR (200MHz, CDCl3) delta ppm 7.35-7.43 (m, 1H), 7.45-7.52 (m, 1H), 7.92 (d, J=2.2Hz, 1H), 8.03 (d, J=0.9Hz, 1H); MS ESI/APCI Dual m/z 195 [M-H]-.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-2-methylaniline, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Matsuda, Daisuke; Kobashi, Yohei; Mikami, Ayako; Kawamura, Madoka; Shiozawa, Fumiyasu; Kawabe, Kenichi; Hamada, Makoto; Nishimoto, Shinichi; Kimura, Kayo; Miyoshi, Masako; Takayama, Noriko; Kakinuma, Hiroyuki; Ohtake, Norikazu; Bioorganic and Medicinal Chemistry; vol. 25; 16; (2017); p. 4339 – 4354;,
Bromide – Wikipedia,
bromide – Wiktionary