These common heterocyclic compound, 2270-59-9, name is 5-Bromo-2-methylpent-2-ene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 2270-59-9
To a mixture of 7-chloro-3-(2-(6-cyclopropyl-lH-indol-3-yl)-2-oxoethoxy)- 2-naphthamide (419mg, 1 mmol) in anhydrous DMF (10 mL) were added 5-bromo-2-methylpent-2-ene (0.6 g, 4 mmol) and K2CO3 (400 mg, 2.9 mmol).The reaction mixture was stirred at 20C overnight then concentrated under high vacuum. The residue was purified by column chromatography to afford the desired product (450 mg, 92.2% yield) as white solid. LC-MS: m/z 501(M+H)+.
The synthetic route of 5-Bromo-2-methylpent-2-ene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SPERO THERAPEUTICS, INC.; ZAHLER, Robert; (262 pag.)WO2016/112088; (2016); A1;,
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