Reference of 418762-26-2, These common heterocyclic compound, 418762-26-2, name is 4-Bromo-2-fluoro-5-methylaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
EXAMPLE 73 7-(2,6-dichlorobenzyl)-5-{ [2-fluoro-5-methyl-4-(piperazin-l -yl)phenyl]amino}pyrido[3,4- d]pyridazin-4(3H)-one EXAMPLE 73A /V,jV-dibenzy l-4-bromo-2-fluoro-5-methylbenzenamineA suspension of 4-bromo-2-fluoro-5-methylbenzenamine (1 g, 4.9 mmol), benzylbromide (2.5 g, 14.7 mmol) and potassium carbonate (2 g, 14.7 mmol) in acetonitrile (80 mL) was heated in a sealed tube at 100C for 16 hours. After concentration, the residue was diluted with ethyl acetate (80 mL) and washed with water (20 mL). The organic layer was dried over anhydrous sodium sulfate, filtered, concentrated and purified by flash chromatography on silica gel (200-300 mesh) eluting with 50/1 petroleum ether/ethyl acetate to give the title compound. MS : 384 (M+H+).
Statistics shows that 4-Bromo-2-fluoro-5-methylaniline is playing an increasingly important role. we look forward to future research findings about 418762-26-2.
Reference:
Patent; ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.; VASUDEVAN, Anil; PENNING, Thomas Dale; CHEN, Huanming; LIANG, Bo; WANG, Shaohui; ZHAO, Zhongqiang; CHAI, Dikun; YANG, Leifu; GAO, Yingxiang; WO2012/97682; (2012); A1;,
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