Synthetic Route of 10016-52-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan, This compound has unique chemical properties. The synthetic route is as follows.
Under a stream of nitrogen, 0.46 g (1.4 mmol) of 2,8-dibromodibenzofuran (manufactured by Sigma-Aldrich Co. LLC.) and 0.90 g (2.8 mmol) of Exemplified Compound 18-1 were added to 15 ml of DMSO and 0.89 g (4.2 mmol) of potassium phosphate and stirred for 10 minutes. To the resultant, 53 mg (0.28 mmol) of CuI and 6-methyl picolinic acid (0.56 mmol) were added and heated at 125 C. for 7 hours. Under cooling with water, 5 ml of water was added thereto and stirred for 1 hour. The precipitated crude product was filtered, further subjected to the column purification, and then recrystallized with o-dichlorobenzene/acetonitrile so as to obtain 0.80 g (yield of 71%) of Exemplified Compound 18.
The chemical industry reduces the impact on the environment during synthesis 2,8-Dibromodibenzo[b,d]furan. I believe this compound will play a more active role in future production and life.
Reference:
Patent; KONICA MINOLTA, INC.; Okubo, Yasushi; Itoh, Hiroaki; Wachi, Ayako; Ishidai, Hiroshi; (69 pag.)US9941422; (2018); B2;,
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