In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2255-80-3 as follows. Product Details of 2255-80-3
4-Bromo-7-methylbenzo[c][l,2,5]thiadiazole (0.5 g, 2.2 mmol) was suspended in methanol (7 ml) and warmed to 45 0C (internal temperature). The suspension was then treated with magnesium turnings (0.42 g, 17.6 mmol) and stirred for 30 mins. The reaction was then cooled and the methanol removed in vacuo. The residue was then mixed with aq. NH4Cl and extracted with EtOAc (3 x 30 ml). The organic layers were dried over MgSO4, filtered, concentrated and dried in vacuo to afford 3-bromo- 6-methylbenzene-l,2-diamine (0.39 g, 94%); deltaH(400 MHz, CDCl3) 6.88 (IH, d, J 8, Ar-H), 6.47 (1H, d, J 8, Ar-H), 3.60 (4H, bs, Ar-NH2), 2.16 (3H, s, ArCH3); m/z (EI) 202 ([81Br]M+, 95%), 200 ([79Br]M+, 100%), 120 (M+ -Br, 75%); the resultant solid was used directly in the next stage.46.
According to the analysis of related databases, 2255-80-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; UNIVERSITY OF DURHAM; WO2009/34396; (2009); A2;,
Bromide – Wikipedia,
bromide – Wiktionary