Related Products of 3972-64-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3972-64-3, name is 1-Bromo-3-(tert-butyl)benzene, This compound has unique chemical properties. The synthetic route is as follows.
A mixture of 2-amino-3,4-dichlorobenzoic acid (1.5 g, 7.3 mmol, 1.0 eq), 11a (3 g, 14.6 mmol, 2.0 eq), potassium carbonate (2.0 g, 14.6 mmol, 2.0 eq), L-proline (252.0 mg, 2.18 mmol, 0.3 eq), and Copper(i) oxide (406.0 mg, 2.19 mmol, 0.3 eq) in 2-Pentanoi (30.0 mL) was stirred at 130 °C overnight under argon atmosphere, then cooled to room temperature, water (20.0 mL) was added. The mixture was filtered through celite. The filtrate was acidified to pH=2 with 2 N HQ, then water (50.0 ml.) was added. The resulting mixture was extracted with EtOAc (50.0 mL x 3). Tire combined organic layers were washed with brine (20.0 mL x 5), dried over anhydrous NazSCL and filtered. The filtrate was concentrated vacuo to afford crude 11b (1.7 g, 69 percent). LC/MS: 338.1 [M+H]+.
The chemical industry reduces the impact on the environment during synthesis 1-Bromo-3-(tert-butyl)benzene. I believe this compound will play a more active role in future production and life.
Reference:
Patent; SILICON SWAT, INC.; CHAMBERLAIN, Brian T.; RICE, James M.; JERNIGAN, Finith E., III; SHERMAN, Woody; KULKARNI, Meghana M.; SHECHTER, Sharon; ALLEN, Bryce K.; TAN, Dazhi; MARINO, Kristen A.; LIN, Zhixiong; (292 pag.)WO2019/100061; (2019); A1;,
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