Electric Literature of 112734-22-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 112734-22-2, name is (4-Bromo-2-fluorophenyl)methanamine, This compound has unique chemical properties. The synthetic route is as follows.
Step 1: To a stirred solution of (4-bromo-2-fluorophenyl)methanamine (25 g, 122.5 mmol) in pyridine (100 mL) at 0 C. in a protective gas atmosphere was added methanesulfonyl chloride (14.22 mL, 183.8 mmol) slowly in portions. After addition, the suspension was stirred at 0 C. for 1 h. The reaction mixture was diluted with ice cold water (20 mL) and pH was adjusted to ?1 using 16% aqueous HCl solution. The resulting precipitation was filtered off, washed with ethyl acetate (3×20 mL) and dried overnight. The crude N-(4-bromo-2-fluorobenzyl)methanesulfonamide (29.24 g, 85%) was used as such without further purification.
The chemical industry reduces the impact on the environment during synthesis (4-Bromo-2-fluorophenyl)methanamine. I believe this compound will play a more active role in future production and life.
Reference:
Patent; FRANK, Robert; BAHRENBERG, Gregor; CHRISTOPH, Thomas; LESCH, Bernhard; LEE, Jeewoo; US2013/79373; (2013); A1;,
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