615-59-8, name is 1,4-Dibromo-2-methylbenzene, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 1,4-Dibromo-2-methylbenzene
(1) Under nitrogen protection, 4.33 g (24 mmol) of 4-methoxycarbonylbenzeneboronic acid, 6 g (40 mmol) of cesium fluoride were placed in a 250 ml three-necked flask, and 150 ml of 1,4-dioxane and 2.754 ml (10 mmol) were added. a mixed solution of 2,5-dibromotoluene,Then 1.6 g of tetrakis(triphenylphosphine)palladium catalyst was added and refluxed at 90 C for 48 h.After the reaction was completed, an orange solution was obtained with a black precipitate. The system was evaporated to dryness under reduced pressure.A white product of 3.0 g was obtained in a yield of 82%.
The synthetic route of 615-59-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shandong Normal University; Dong Yubin; Wang Jiancheng; Liu Congxue; (14 pag.)CN109988079; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary