Related Products of 67344-77-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 67344-77-8, name is 1-(3-Bromophenyl)-N-methylmethanamine, This compound has unique chemical properties. The synthetic route is as follows.
Intermediate A (1.50 g, 7.5 mmol), pyridine-3-boronic acid (0.97 g, 7.9 mmol), Pd(PPh3)4 (0.44 g, 0.38 mmol) and K2C03 (2.68 g, 18.8 mmol) were placed in a 20 mL microwave reaction vial. The vessel was sealed with a crimp-cap septum and then was twice evacuated under hi- vacuum and flushed with nitrogen. THF (11 .5 mL) and H20 (5.5 mL) were added by syringe, theevacuation/nitrogen flush procedure was repeated and the vessel contents were then heated at reflux 0/N. After cooling to rt, the reaction mixture was partitioned between Et0Ac and H20 and the layers were separated. The aqueous layer was extracted twice with Et0Ac and the organic phases were combined, dried over MgS04 and concentrated in vacuo. Flash chromatography of the residue on silica gel eluting with an increasing proportion of Me0H (0.5 to 10percent) in DCM andevaporation of solvents in vacuo afforded Intermediate B as a faint-orange oil.
The chemical industry reduces the impact on the environment during synthesis 1-(3-Bromophenyl)-N-methylmethanamine. I believe this compound will play a more active role in future production and life.
Reference:
Patent; VAL-CHUM, LIMITED PARTNERSHIP; MADIRAJU, S.R. Murthy; PRENTKI, Marc; JOLY, Erik; ZHAO, Shangang; WO2015/127559; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary