Reference of 112279-72-8,Some common heterocyclic compound, 112279-72-8, name is 4-Bromo-2,3-difluoroaniline, molecular formula is C6H4BrF2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of Compound (G-2) (78 g, 375 mmol) in anhydrous dichloromethane (250 mL) was added acetic anhydride (53.2 ml, 563 mmol) at room temperature, then the reaction mixture was stirred for 1 hour. After the completion of the reaction, the insoluble residue was collected by filtration to give Compound (G-3) (85.3 g, 91%).Compound (G-3);1H-NMR (DMSO-d6) delta: 2.10 (s, 3H), 7.48 (t, J=7.2 Hz, 1H), 7.72 (t, J=7.2 Hz, 1H), 10.32 (s, 1H).
The synthetic route of 112279-72-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shionogi & Co., Ltd.; US2012/253040; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary