10546-67-5, name is 2,6-Dibromo-4-(tert-butyl)aniline, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C10H13Br2N
Example 2.1 : (0854) Preparation of N-(2,6-dibromo-4-(tert-butyl)phenyl)phthalamide (0855) A mixture of phthalic anhydride (5.00 g, 33.76 mmol) and 2,6-dibromo-4-tert-butyl aniline (12.44 g, 40.51 mmol) was dissolved in 50 mL of acetic acid and refluxed for 12 h. The reaction was monitored by TLC (petroleum ether/ethyl acetate, 5/1 ), upon completion the solvent was evaporated under reduced pressure and the residue was recrystallized from methanol to give the desired product as colorless well-defined crystalls. Yield 1 1 .60 g (78%). (0856) 1H NMR (300 M Hz, CDCI3, 298K) delta 1 .34 (s, 9H), 7.67 (s, 2H), 7.83 (dd, J = 5.5, 3.1 Hz, 2H), 8.00 (dd, J = 5.5, 3.1 Hz, 2H). (0857) 13C NMR (75 MHz, CDCI3, 298K) delta 31.14 (3C, CH3), 35.35 (1 C, C-CH3), 124.26, 124.64, 129.99, 131 .97, 134.69, 156.20, 165.97 (2C, C=0). (0858) FD mass spectrum (8 kV): m/z (%): calculated: 437.13; found: 437.20 (100) [M]+.
The synthetic route of 10546-67-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BASF SE; MAX-PLANCK-GESELLSCHAFT ZUR FOeRDERUNG DER WISSENSCHAFTEN E. V.; BASF (CHINA) COMPANY LIMITED; GESSNER, Thomas; REICHELT, Helmut; WEITZ, Thomas; EUSTACHI, Michael; JAeNSCH, Daniel; CHEN, Long; SKABEEV, Artem Nikolaevich; MUeLLEN, Klaus; REICHERT, Hans; WO2015/125125; (2015); A1;,
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