Some common heterocyclic compound, 591-19-5, name is 3-Bromoaniline, molecular formula is C6H6BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C6H6BrN
Under nitrogen or argon atmosphere, 3-bromoaniline 0.4 mmol, 0. 2 mm ? Ir (ppy) (2 mg) And DMF (1 ml) were added to the reaction flask and then irradiated with a blue LED band (7W) at room temperature until complete conversion of the trivalent iodine reagent was completed. 10 ml of a saturated aqueous Na2C03 solution was added thereto, and the mixture was extracted three times with ethyl acetate. The organic layer was washed once with saturated brine, and the organic layer was dried over anhydrous Na2S04. Column chromatography (eluent: petroleum ether 60-90: ethyl acetate = 20: 1-10: 1) to afford the product NIH2Yield 27%; CF3 ? Br ^ A ^ NH2CF, yield 23%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 591-19-5, its application will become more common.
Reference:
Patent; Nanjing University; Zhu, ChengJian; Xie, jin; Xu, Pan; (13 pag.)CN103553857; (2016); B;,
Bromide – Wikipedia,
bromide – Wiktionary