Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1295502-53-2, name is 4,7-Dibromo-5,6-difluorobenzo[c][1,2,5]thiadiazole, A new synthetic method of this compound is introduced below., Application In Synthesis of 4,7-Dibromo-5,6-difluorobenzo[c][1,2,5]thiadiazole
Dry 250mL three-necked flask was added compound 2 (3.87g, 5mmol), 4,7- dibromo-5,6-difluorobenzo [c] [1,2,5] thiadiazole (1.65g, 5mmol) , 120mL THF, and Pd (PPh3)Cl2(105mg, 0.15mmol); and dissolved with stirring, using a vacuum pump with nitrogen 3 times; the reaction temperature was raised to 70 24 hours; direct cooling to room temperature rotary evaporation, and dichloromethane: petroleum ether (1: 5) as eluent agent over a silica gel column to give an orange solid component is the desired product (1.97 g of, 46% yield);
The synthetic route of 1295502-53-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; National Center for Nanoscience and Technology (NCNST); Wei, Zhixiang; Yuan, liu; (22 pag.)CN105315273; (2016); A;,
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