Reference of 6698-13-1,Some common heterocyclic compound, 6698-13-1, name is 4-Bromo-1,3-benzodioxole, molecular formula is C7H5BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
4.1.3.1. 1-(Benzofuran-7-yl)-3-(dimethylamino)propan-1-one (V:class D-7). A solution of 7-bromobenzofuran (2.05 g, 10.4 mmol)in dry THF (20 mL) was prepared. Approximately 4 mL of this solutionwas added to a flask containing magnesium (0.75 g, 30.9mmol) and the mixture was agitated until an exothermic reactionoccurred. The remaining solution was added and the mixture wasrefluxed for 1 h, cooled and transferred by cannula to a dry flask.The solution was cooled to 0 C and acetaldehyde (0.70 mL, 12.3mmol) was added, the mixture was stirred at 0 C for 1 h then partitionedbetween EtOAc and water, the organic fractions were dried and evaporated. Column chromatography with hexanes:DCM(1:1) eluted non polar impurities, elution with DCM
The synthetic route of 6698-13-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Sutherland, Hamish S.; Tong, Amy S.T.; Choi, Peter J.; Conole, Daniel; Blaser, Adrian; Franzblau, Scott G.; Cooper, Christopher B.; Upton, Anna M.; Lotlikar, Manisha U.; Denny, William A.; Palmer, Brian D.; Bioorganic and Medicinal Chemistry; vol. 26; 8; (2018); p. 1797 – 1809;,
Bromide – Wikipedia,
bromide – Wiktionary