In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 41825-73-4 as follows. Recommanded Product: 2-Bromo-4,6-dimethylaniline
General procedure: To a stirred solution of the corresponding aniline (1 mmol),Cs2CO3 (2 mmol), and Pd(PPh3)4 (5 mol%) in toluene (20mL) at reflux and under nitrogen atmosphere, a solution ofN-Boc-pyrrol-2-yl boronic acid17 (1 mmol) in a mixture oftoluene (10 mL) and MeOH (3 mL) was added over 7 h. Themixture was stirred at reflux for 17 h, cooled, and the MeOHwas removed under reduced pressure. To the resultanttoluene suspension H2O (30 mL) was added, and the layerswere separated. The water layer was extracted with CH2Cl2(3 × 25 mL; or EtOAc for compound 5), the combinedorganic extracts were washed with H2O (30 mL), dried overMgSO4, filtered, and the solvent was evaporated underreduced pressure. The residue was purified by columnchromatography on silica gel using a suitable eluent asindicated below.
According to the analysis of related databases, 41825-73-4, the application of this compound in the production field has become more and more popular.
Reference:
Article; Petrov?i?, Matija; Ale?kovi?, Marija; Mlinari?-Majerski, Kata; Synlett; vol. 25; 19; (2014); p. 2769 – 2772;,
Bromide – Wikipedia,
bromide – Wiktionary