Electric Literature of 60956-23-2,Some common heterocyclic compound, 60956-23-2, name is 1,2-Dibromo-4-methylbenzene, molecular formula is C7H6Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Fuel additive d was prepared according to the following scheme: The fuel additive was prepared using the following procedure: to a set of reaction tubes (dimensions 110 mm x 17 mm) was weighed the catalysts and bases by use of a Mettler Toledo FlexiWeigh automated solid dispenser. Separate tubes were used for the catalyst and for the base and internal standard. To the catalyst tube containing Pd2(dba)3 (14 mg, 0.016 mmol) and XPhos (30 mg, 0.062 mmol) was added tert- amyl alcohol (1 mL) and heated with stirring to 60 C for 0.5 hours before cooling to ambient temperature. To each reaction tube of pre-weighed potassium carbonate as base (94 mg, 0.68 mmol) and di-/er/-butyl biphenyl (12 mg) as internal standard was added tert- amyl alcohol (2 mL) with stirring and the liquid reagents dichlorotoluene (80 pL; 0.62 mmol) and ethanolamine (75 pL, 1.24 mmol) added. Subsequently, the 1 mL of pre-formed?Pd-XPhos? catalyst solution was charged to the main reaction tube and the resulting reaction mixture heated to 90 C with a chilled- condenser head block to avoid solvent loss. Sampling of the reaction was conducted manually extracting an aliquot by syringe or Eppendorf pipette at 0, 2 and 16 hours. The reaction was repeated using the same procedure, but modified in line with conditions in the following table:
The synthetic route of 60956-23-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BP OIL INTERNATIONAL LIMITED; FILIP, Sorin, Vasile; GAUNT, Matthew; (23 pag.)WO2019/129594; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary