Electric Literature of 1435-54-7,Some common heterocyclic compound, 1435-54-7, name is 1,3-Dibromo-2-fluorobenzene, molecular formula is C6H3Br2F, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2-isopropylphenol 0.1mol, dissolved in 100mL anhydrous tetrahydrofuran, stirring, accurately weighed 0.4mol sodium hydride in batches added to the reaction bottle, not too fast to prevent too much bubbles. After adding the solution turned yellow, then add 1,3-dibromo-2-fluorobenzene 0.11mol, also added in batches, room temperature overnight. The resulting reaction product was filtered to remove the solid material, the filtrate was dry and dissolved in dichloromethane. The column was washed with petroleum ether: ethyl acetate = 1: 5 (volume ratio) to give 1,3-dibromo-2-(2-isopropylphenoxy)benzene (Intermediate A-1) (0.05 mol, y = 50%).
The synthetic route of 1435-54-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Jilin Optical and Electronic Materials Co., Ltd.; Cui, Dunzhu; Gao, Chunji; Wang, Hui; Ma, Xiaoyu; Zhao, He; Li, Ming; Li, Wenjun; (65 pag.)CN106146538; (2016); A;,
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