Adding a certain compound to certain chemical reactions, such as: 202865-77-8, name is 2-Bromo-4-fluoro-6-methylaniline, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 202865-77-8, Safety of 2-Bromo-4-fluoro-6-methylaniline
Referential Example 10 Synthesis of 2-Bromo-5-fluoro-4-methylaniline Iron powder (18.5 g) was added to a solution of 5-bromo-2-fluoro-4-nitrotoluene (9.7 g) in acetic acid (30 ml), and the mixture was stirred at 70 C. for 3 hours. The catalyst was removed by filtration through Celite, and the filtrate was washed with chloroform. The solvent and the like in the filtrate were distilled off under reduced pressure. The residue was subjected to column chromatography on silica gel to conduct elution with chloroform, thereby obtaining the title compound (7.9 g) as a red oil. 1 H-NMR (CDCl3) delta: 2.13(s,3H), 6.46(d,J=11 Hz,1H), 7.20(d,J=8 Hz,1H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-4-fluoro-6-methylaniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Wakunaga Pharmaceutical Co., Ltd.; US6136823; (2000); A;,
Bromide – Wikipedia,
bromide – Wiktionary