Synthetic Route of 21865-50-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 21865-50-9, name is 6-Bromo-2,3,4,9-tetrahydro-1H-carbazole, This compound has unique chemical properties. The synthetic route is as follows.
To a solution of 6-bromo-2,3,4,9-tetrahydro-lH-carbazole (66 mg, 0.27 mmol) inDMF (3 ml) was added NaH (60% in mineral oil, 16 mg, 0.41 mmol) and tetrabutylammonium iodide (151 mg, 0.41 mmol). The resulting mixture was stirred at room temperature for 10 min and followed by addition of l-(3-chloropropoxy)-3,5- difluorobenzene (55 mg, 0.27 mmol). The reaction mixture was stirred at room temperature overnight, poured into H2O (30 ml), and extracted with EtOAc (3 x 30 ml). The organic layers were combined, dried over MgSO4, filtered and cone, in vacuo. The crude product was purified by silica gel flash chromatography (EtOAc/hexane, 0-20%) to give the title compound (colorless oil, 53 mg). The yield: 46.7%.
The chemical industry reduces the impact on the environment during synthesis 6-Bromo-2,3,4,9-tetrahydro-1H-carbazole. I believe this compound will play a more active role in future production and life.
Reference:
Patent; ITHERX PHARMACEUTICALS, INC.; WO2009/103022; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary