In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 41825-73-4, name is 2-Bromo-4,6-dimethylaniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 2-Bromo-4,6-dimethylaniline
a) Synthesis of A/-(2-bromo-4,6-dirnethyl-phenyl)-iH-benzimidazol-2-amine 2-Chlorobenzimidazole (6.9 g, 45.4 mmol) and 2-bromo-4,6-dimethylaniline (10.0 g, 50.0 mmol) are dissolved in NMP (23 imL) at 20C. Methanesulfonic acid (4.8 g, 50.0 mmol) is added dropwise over ca. 0.5 h. The resulting suspension is heated to 100C and stirred until complete conversion of 2-chlorobenzimidazole. The reaction mixture is then cooled to 20C, diluted with water (14 ml.) and neutralized with 30 w-% aqueous sodium hydroxide (12.7 g, 95.3 mmol). The precipitated reaction product is isolated by filtration, washed with water and dried under vacuum at 90C. Crude A/-(2-bromo-4,6-dimethyl-phenyl)- iH- benzimidazol-2-amine (10.3 g, 72%) is obtained as an off-white amorphous solid, which was further purified by recrystallization from methanol. 1 H-NMR (DMSO-d6): delta = 2.21 (s, 3H), 2.31 (s, 3H), 6.83-6.95 (m, 2H), 7.06-7.18 (m, 3H), 7.39 (brs, 1 H), 8.58 (brs, 1 H), 10.75 (brs, 1 H) ppm.
The synthetic route of 41825-73-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; UDC IRELAND LIMITED; GREEF, DE, Michiel; PETER, Bernd; STUMPF, Ruediger; (36 pag.)WO2017/17096; (2017); A1;,
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